PrEP is ~99% effective at preventing HIV through sex1*
CDC guidelines state individuals should be reminded that PrEP medications do not protect against other STIs, and condoms should be considered part of a comprehensive safer sex practice.1
Condoms have been shown to be 70% (men who have sex with men) and 80% (heterosexual couples) effective at preventing HIV2†
*When taken as prescribed.1
†CDC has stated that condom efficacy may be higher when used correctly.3
CDC=Centers for Disease Control and Prevention; PrEP=pre-exposure prophylaxis;
STIs=sexually transmitted infections.
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USPSTF=US Preventive Services Task Force.
References:
1. Centers for Disease Control and Prevention. HIV Nexus: CDC resources for clinicians. Updated August 20, 2024. Accessed June 16, 2026. https://www.cdc.gov/hivnexus/hcp/prep/index.html
2. Smith DK, Herbst JH, Zhang X, Rose CE. Condom effectiveness for HIV prevention by consistency of use among men who have sex with men in the United States. J Acquir Immune Defic Syndr. 2015;68(3):337-344.
3. US Preventive Services Task Force; Owens DK, Davidson KW, Krist AH, et al. Preexposure prophylaxis for the prevention of HIV infection: US Preventive Services Task Force recommendation statement. JAMA. 2019;321(22):2203-2213.